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pentobarbital will reduce the extent or influence of estradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will decrease the level or outcome of exemestane by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. For clients getting exemestane that has a potent CYP3A4 induce